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The use of anabolic steroids has been linked to many forms of liver toxicity such as hepatic tumours and chronic vascular injury to the liver. A recent case series on a young man was described by Zawadzki et al.23 In this patient, liver cancer was diagnosed only 30% after 12 years, with survival being 5 years. This patient’s use of anabolic steroids was related to a low physical appearance and the use of a new sports training method that emphasized hypertrophy and increased the risk of injury during exercise.24 On a general level, liver function tests in men and women are not equivalent to those observed in men and women with a high prevalence of cancer.10,25,26
The current use of anabolic steroids is common among college students of different ethnic groups in Eastern Europe26 and is one of the most pervasive substances used over this period.27 The incidence of hepatotoxicity and the number of cases can be estimated from the data available from the literature. In the majority of cases, a positive result in serum testosterone or free testosterone androstenone levels has been found in patients, despite negative serum free androstenedione.27 Furthermore, both testosterone androstenedione are thought to have potential carcinogenicity.28–32
The potential carcinogenicity of anabolic steroids cannot be fully clarified on the basis of the current knowledge, especially because there are conflicting data by individual studies. The literature shows that anabolic steroids can produce increased levels of the urinary 2-phenylpropanolamine metabolite, 2-propanolamine, and a positive, even negative, test result has been reported in 2 studies.30,31 The present study will provide the main results of the present study on a new study design using serum 2-propanolamine.
An objective of the present study was the first description of the prevalence of severe liver failure that occurred in a group of athletes with frequent intake of anabolic steroids, particularly in those who were involved in weight training and the amount of training performed.
A sample selection
A total of 48 athletes with frequent use of anabolic steroids were identified and randomized to a single treatment group or another treatment and control group. The first patient included in the study is representative in terms of demographic background, physical function and previous diagnoses. He was diagnosed with idiopathic chronic liver failure, a liver disorder that is characterized by decreased hepatic metabolism and the development of liver cancer. His age was 39 years, body mass index 40.2 kg/m2 and his body height was 168 cm. He used anabolic steroids in his professional career
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